In a communitybased prospective cohort with contemporaneous followup of comparable duration tilda, participants 75 years of age or older who met inclusion criteria for sprint had rates of injurious falls and syncope approximately 5fold higher than the standard care group in sprint. Effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with hypertension. Management of symptomatic orthostatic hypotension see manual of. Cox proportional hazards regression was used to identify independent predictors of the sprint primary outcome and adverse events. The systolic blood pressure sbp intervention trial. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure sbp to a lower goal than currently recommended will reduce cardiovascular disease cvd risk. One possible extension of the sprint findings might be to individuals who are. Generalizability of results from the systolic blood pressure intervention trial. Listing a study does not mean it has been evaluated by the u. Blood pressure variability predicts adverse events and. Systolic blood pressure intervention trial full text view. According to the original paper of sprint,12 a total of 9361 participants from the united states and puerto rico were re. Sprint csr the official site for press releases, photos, video, audio, pr contact information, presskits and more.
Cushman, md chief, preventive medicine, memphis va medical center. A randomized trial of intensive versus standard bloodpressure. Out of a total of 143 sprint challenge submissions, 29 submissions met our inclusionexclusion criteria and were included for analysis online supplementary appendix i. Apply jnc8 recommendations and the sprint trial results appropriately in clinical practice. Pulmonary artery pressureguided management of patients. The systolic blood pressure intervention trial sprint the sprint study research group abstract. Systolic blood pressure intervention trial sprint principal results paul k. A randomized trial of intensive versus standard blood. Tanner rm, hess r, colantonio ld, shimbo d, muntner p.
Injurious falls and syncope in older communitydwelling. The systolic blood pressure intervention trial sprint. These results thus provide further validation of the 2015 lipid guidelines approach. Antihypertensive drug management to achieve systolic blood pressure criteria 12, 17. In a clinical trial, the investigators must specify inclusion and exclusion criteria for participation in the study inclusion criteria are characteristics that the prospective subjects must have if they are to be included in the study, while exclusion criteria are those characteristics that disqualify prospective subjects from inclusion in the study.
Supplementary appendix this appendix has been provided by the authors to give readers additional information about their work. Whelton, mb, md, msc chair, sprint steering committee tulane university school of public health and tropical medicine, and school of medicine for the sprint research group. Patients were randomized to intensive bp control targeting sbp sprint methods and results. Increased cardiovascular risk was one of the inclusion criteria.
Systolic blood pressure intervention trial sprint principal results. Ambulatory blood pressure in hypertensive patients with. The most common reason for exclusion was that the submission contained no prediction models. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf link from 2007, which identified the question of targeting low blood pressure i. Submissions from the sprint data analysis challenge on. Ambulatory blood pressure in hypertensive patients with inclusion criteria for the sprint trial. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized. The objective of setting inclusionexclusion criteria is to identify a trial. Bp values and categories in patients with inclusionexclusion criteria of the systolic blood pressure intervention sprint trial from. Generalizability of the sprint results nejm journal watch.
With at least one of the following cv risk factors. A complete list of the members of the systolic blood pressure intervention trial sprint research group is provided in the supplementary appendix, available at. Systolic blood pressure intervention trial sprint protocol version. Systolic blood pressure intervention trial sprint is an unmasked openlabel randomized controlled clinical trial examining the effect of a high blood pressure treatment strategy aimed at reducing systolic blood pressure sbp to a lower goal than is currently recommended. Patients with any lvef were included in the trial, but inclusion criteria for patients with hfref required established therapies with acei or arb and bb at optimal or besttolerated doses before randomization unless a contraindication or intolerance was documented. Systolic blood pressure intervention trial american. Sprint randomized trial of tibial fracture fixation. Jackie bosch at the american college of cardiology. A randomized trial of intensive versus standard bloodpressure control.