Every 3second burst of the hifu beam heats the target tissue to 88. Similar to sound, the key parameters of ultrasound are wave amplitude and wave frequency measured in cycles per second or hertz hz. An early history of highintensity focused ultrasound. Highintensity focused ultrasound ablation in hepatic and. The earliest attempts at focused ultrasound therapy were simply targeted by using xrays or ultrasound. Sonic intensity, defined as energy passing through unit area within unit time, is derived from plane wave.
In the short term, highintensity focused ultrasound seems to have fewer side effects than other cancer treatments. Highintensity focused ultrasound is a rel atively new technique that has great poten tial for further development. Guttlers life in pictures 2012 example of a biopsy called class iii but was inadequate due to bloody distortion artifacts. An early history of highintensity focused ultrasound william d. Standard treatments are currently limited to chemotherapy, radiotherapy, or a combination of the two. Unlike diagnostic ultrasound, hifu focuses the ultrasound waves precisely upon a target.
High intensity focused ultrasound hifu uses high frequency ultrasound energy to heat and destroy cancer cells in the prostate. A beam of ultrasound energy travels into the prostate from a probe put into the back passage rectum. High intensity focused ultrasound, or hifu, is a therapy option for prostate cancer patients where the tumor is still confined to the organ and has not spread to other areas of the body. In high intensity focused ultrasound hifu, a specially designed transducer is used to focus a beam of ultrasound energy into a small volume at specific target locations within the body. Hifu can be used to increase the flow of blood or lymph, or to destroy tissue, such as tumors, through a number of mechanisms. High intensity focused ultrasound hifu prostate cancer uk. Hifu is different from cryotherapy in that the focal zone is extremely discrete with little or no tissue effects in. Highintensity focused ultrasound radiology reference. Focused ultrasound surgery fus is a noninvasive technique. To achieve this, high intensity focused ultrasound hifu waves are accurately coupled through the skin and aimed at the target volume, e.
High intensity focused ultrasound hifu machine hifu. Mar 11, 2014 hifu or high intensity focused ultrasound is a noninvasive, extremely precise procedure that uses ultrasound to heat and destroy uterine fibroid. High intensity focused ultrasound revised april 2014 number. You may hear your doctor call it noninvasive, which means a surgeon doesnt have to cut. High intensity focused ultrasound hifu for pancreatic carcinoma.
As a noninvasive approach, high intensity focused ultrasound therapy can selectively ablate a targeted lesion of the pancreas. An ultrasound probe focuses sound waves to an area as small as a grain of rice, similar to sunlight focused by a magnifying glass, elevating the tissue temperature to a point that the tissue cannot survive 70 to90 degrees. A highintensity focused ultrasound hifu procedure is a technique approved by the fda to remove prostate tissue. High intensity focused ultrasound hifu is gaining rapid clinical acceptance as a treatment modality enabling noninvasive tissue heating and ablation for. Uchida t, nakano m, hongo s, shoji s, nagata y, satoh t, et al. Hifu or high intensity focused ultrasound is a noninvasive, extremely precise procedure that uses ultrasound to heat and destroy uterine fibroid.
Highintensity focused ultrasound hifu is a noninvasive therapeutic technique that uses nonionizing ultrasonic waves to heat tissue. Studies have used highintensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and chronic pain while sparing the overlying and. From january 2006 to december 2008, 3 sessions of hifu treatment were performed in 114 consecutive patients with primary hepatic tumor n 57, hepatic metastasis n 22, and pancreatic cancer n 35 under general anesthesia. High intensity focused ultrasound procedure for prostate cancer. Review clinical application of highintensity focused. Electrophysiological study 6 months after epicor highintensity focused ultrasound atrial. Garcia r, sacher f, oses p, derval n, barandon l, denis a, hocini m, roques x, haissaguerre m, labrousse l, jais p. High intensity focused ultrasound hifs is the use of highfrequency sound waves focused on a tumour to generate extreme heat in that particular area, killing off the malicious cancer cells targeted without damaging the surrounding tissue. Though it hasnt been approved for the treatment of prostate cancer in the u. In the short term, high intensity focused ultrasound seems to have fewer side effects than other cancer treatments. High intensity focused ultrasound, or hifu, is a treatment that has only recently obtained fda approval in the united states.
In the field of oncology, the use of hifu to noninvasively cause tissue necrosis in a defined target, a technique known as focused ultrasound surgery fus, has considerable potential for tumour ablation. The main reason for this has been the lack of a way to monitor procedures. Highintensity focused ultrasound hifu or fus is a medical procedure that applies highintensity focused sonic energy to locally heat and destroy diseased or damaged tissue through ablation. Obrien jr and floyd dunn foresighted leadership, the gi bill, and research conducted in an unventilated steam tunnel all contributed to the development of a now ubiquitous medical tool. Ultrasound waves are acoustic pressure waves that have a frequency range that begins at the limit of human hearing, 20 khz, and extends well into the megahertz range. The effect of the scanning pathway in highintensity focused. High intensity focused ultrasound target at fat of mmdepth of penetration, heating up the fat tissue, combine with high energy and good penetration to resolve the fat, during the treatment, the triglyceride and fatty acid excrete by the process of metabolism, and the vessal and nurve will not be damaged. This is also true for high intensity focused ultrasound, with each company bringing their take on the technology to the table it can be diffcult to separate marketing from real results. High intensity focused ultrasound other treatments. Jan 17, 20 high intensity focused ultrasound hifu is a rapidly maturing technology with diverse clinical applications.
Pdf an introduction to high intensity focused ultrasound. Clinical application of highintensity focused ultrasound in cancer. A highintensity focused ultrasound hifu procedure is one of the newest ways to treat prostate cancer. European radiology 2016 volume 26 number 11 pages 40474056. While the process is not intended to boil an organ, more physicians are seeking out this method to heat up and denature the affected tissues. Highintensity focused ultrasound of lesion, and the mdct finding was interpreted therapeutic procedure highintensity focused ultrasound ablation was performed with a system jc hifu, chongqing haifu technology equipped with an ultrasound device for realtime guidance of the treatment. Its used to ablate prostate tissue in a noninvasive way, relying. Clinical trials of highintensity focused ultrasound hifu began in the early 1990s in. Of these, mrghifu is not currently available in ontario. Pdf ultrasound can penetrate deep into tissues and interact with human tissue via thermal and mechanical mechanisms. High intensity focused ultrasound hifu is widely used for the treatment of tumors of various nature, competing with both traditional surgical methods and other noninvasive technologies of bio. Hifu pronounced hifoo, or high intensity focused ultrasound, is an exciting prostate cancer treatment technology that has revolutionized the treatment of prostate cancers. Highintensity focused ultrasound hifu for definitive treatment of prostate cancer.
In the focal area, tissue temperature increases rapidly, within seconds, up to 60 c or higher. Focused ultrasound fus, also called highintensity focused ultrasound hifu, has gained a lot of interest in recent years as noninvasive cancer therapy that does not require radiation, chemotherapy, or surgery, resulting is less collateral damage to the patient. Focused ultrasound fus, also called high intensity focused ultrasound hifu, has gained a lot of interest in recent years as noninvasive cancer therapy that does not require radiation, chemotherapy, or surgery, resulting is less collateral damage to the patient. Recent advances in hifu have increased its popularity. Intensity focused ultrasound of the prostate smiths. Fus is performed as an outpatient procedure, so it can eliminate the usual two weeks of recovery needed from most types of surgery.
High intensity focused ultrasound, or hifu, is an fda approved therapy that destroys tissue with rapid heat elevation, which essentially cooks the tissue. In a similar way to how light can be focused to a burning point by a magnifying glass, ultrasound passes through the body without any effect but generating lethal heat 65 o c exactly where they are focused. Highintensity focused ultrasound hifu is a new technique that can cause cell death and tissue necrosis by focusing high energy ultrasonic waves on a single location, and it has attracted recent interest as a noninvasive therapy particularly for cancer treatment. Highintensity focused ultrasound hifu is emerging as a new modality. The model jc tumour therapy device used in all treatments has previously been described by kennedy et al. Edap, based in lyon, france, now has fda clearance to bring to the u. The focused beam causes localized high temperatures 55 to 90c in a region as small as 1 x 1 x 5 mm. The target tumour was identified using the integrated diagnostic ultrasound transducer 3. Though potential clinical applications of hifu were reported as early.
The information on this page is based on literature searches and specialist checking. Clinical applications of highintensity focused ultrasound. Hifu is able to lead a potential coagulative necrosis indepth tissue without damaging peripheral vital anatomy structures. High intensity focused ultrasound is a noninvasive procedure that is similar to focusing the sun on a leaf with a magnifying glass. High intensity focused ultrasound hifu for fibroid. Hifu application in the palliative treatment of pancreatic.
High intensity focused ultrasound procedure for prostate. High intensity focused ultrasound therapy korean j radiol 94, august 2008 293 fig. Highintensity focused ultrasound is a method that focuses ultrasound to heatablate target tissues without injuring surrounding structures. A high intensity focused ultrasound hifu procedure is a technique approved by the fda to remove prostate tissue. Highintensity focused ultrasound for the treatment of prostate. High intensity focused ultrasound, its effect on medicine. Evolution and outcomes of 3 mhz high intensity focused ultrasound therapy for localized prostate cancer during 15 years. Hifu uses ultrasound waves to neutralize cancerous prostate cells instead of surgery or radiation which eliminates the need for an overnight hospital stay and incisions. High intensity focused ultrasound hifu or hifus is a cancer treatment which uses sound waves at high frequency. Ce 1 introduction high intensity focused ultrasound hifu is a non invasive technique used for provoking thermal ablation within a target, i. High intensity focused ultrasound hifu is a minimally invasive, outpatient, and radiationfree procedure that patients can undergo in a few hours and return home the same day.
Highintensity focused ultrasound hifu therapy, also known as focused ultrasound surgery fus, is a noninvasive technology that delivers ultrasound us. The feasibility of focused ultrasound for thermal therapy has been well established for more than 50 years. Ultrasound beams are focused on fibroid, and accumulative energy of the beam at a focal point increases. Pdf highintensity focused ultrasound attenuates neural. Two basic forms of thermal therapy for treatment of prostate cancer have been developed. However, it has yet to reach wide application in the clinic. High intensity focused ultrasound offers new tumor. Principles and results of highintensity focused ultrasound for. It literally achieves the results of a facelift or a body lifts without any invasive surgery or injections, moreover. To evaluate the complications of highintensity focused ultrasound hifu in patients with hepatic and pancreatic cancer. This advancement in the treatment of prostate cancer is making it possible for patients with earlier stages of the disease to maintain their quality of life without. Past, present, and future in neurosurgery article pdf available in neurosurgical focus 442. The ability of ultrasound to be focused into a small region of interest through the intact skull within the brain has led researchers to investigate its potential therapeutic uses for functional neurosurgery and tumor ablation.
High intensity focused ultrasound thyroid center of. Fry and colleagues are credited with the first application of hifu in humans by producing elevated acoustic intensities in vivo by focusing ultrasound en ergy in a. High intensity focused ultrasound hifu for fibroid uterus. Highintensity focused ultrasound hifu or hifus is a cancer treatment which uses sound waves at high frequency. To evaluate the complications of high intensity focused ultrasound hifu in patients with hepatic and pancreatic cancer. Highintensity focused ultrasound in the treatment of solid. A type of thermotherapy or thermoablation for the treatment of benign prostateic hyperplasia and still under study for the treatment of cancer.
A high intensity focused ultrasound hifu procedure is one of the newest ways to treat prostate cancer. High intensity focused ultrasound semantic scholar. High intensity focused ultrasound other treatments cancer. High intensity focused ultrasound hifu has been successfully used as a novel hyperthermia therapy of tumors in clinical application. At present, a clinical trial on mrghifu is being held at 2 research institutes in the province. High intensity focused ultrasound hifu high intensity focused ultrasound hifu is a minimallyinvasive surgical technique for the thermal ablation of both malignant and benign tumors and cessation of internal bleeding in injured vessels and organs with little.
High intensity focused ultrasound hifu is a rapidly maturing technology with diverse clinical applications. In principle, where surgery usually aims to remove a tumour with an adequate normaltissue margin, if a minimally invasive technique can destroy the equivalent tissue volume, then outcome in terms of diseasefree survival should be at least equal. Other ultrasound treatment methods include ultrasoundassisted drug delivery. High intensity focused ultrasound hifu directly delivers heat energy to skin and subcutaneous tissue that can stimulate and renew the skins collagen and thus consequently improving the texture and reducing sagging of the skin. The technology can be used to treat a range of disorders and as of 2015 is at various stages of development and commercialization.
High intensity focused ultrasound thyroid center of santa. Bill obrienis the director of the bioacoustics research. High intensity focused ultrasound offers new tumor treatment. All treatments were performed prone under general anaesthetic figure 1. First high intensity focused ultrasound system for. Highintensity focused ultrasound hifu is an emerging technology that has potential to use ultrasound energy directly for therapeutic purposes, including ablation and enhancing drug delivery. High intensity focused ultrasound hifu is a needleless, nonionizing, thermal ablation tool. By using the combination of highintensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions precisely. Hifu is one of the few prostate cancer treatments that can be categorized as a minimally invasive, out. First high intensity focused ultrasound system for prostate. Highintensity focused ultrasound treatment of liver. Relationships between sound pressure, power, energy, and intensity. Abstract background highintensity focused ultrasound hifu has been widely accepted as a golden standard procedure for skin tightening.
As seen in equation, intensity is proportional to square of acoustic pressure. Studies have used high intensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and chronic pain while sparing the overlying and. Prostate cancer prostate cancer, accounting for 33 % of all male cancers, is the 2nd leading cause of cancer death in men, exceeded only by lung cancer. Ultrasound therapy, thermal ablation, cancer, heating, high intensity focused ultrasound hifu introduction the aim of most ablative therapies, whether for the treatment of cancer or of benign conditions, is the selective destruction of a targeted tissue volume, leaving surrounding tissues intact. It has long been known that highintensity focused ultrasound hifu can kill tissue through coagulative necrosis. Highintensity focused ultrasound in the treatment of. Pdf highintensity focused ultrasound treatment for. High intensity focused ultrasound hifu is an advanced technology which deploys focused, high energy, controlled ultrasound waves to heat and destroy the areas of the prostate gland affected by cancer. Health quality ontario was asked to investigate the use of. Highintensity focused ultrasound as focal therapy of prostate cancer.
By using the combination of highintensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions. High intensity focused ultrasound hifu or fus is a medical procedure that applies high intensity focused sonic energy to locally heat and destroy diseased or damaged tissue through ablation. With the use of low temperature sensitive liposomes ltsls, high intensity. Highintensity focused ultrasound treatment of liver tumours.
Because of the this, it is not yet widely available in the u. Ultrasound energy, or sound waves, is focused at a specific location and at that focal point, the temperature raises to almost 90 degrees celsius in a matter of seconds. Highintensity focused ultrasound hifu for pancreatic carcinoma. Highintensity focused ultrasound therapy korean j radiol 94, august 2008 293 fig.
Highintensity focused ultrasound therapy for prostate cancer. High intensity focused ultrasound on sales quality high. Hifu prostate cancer treatment western states hifu. High intensity focused ultrasound medical clinical. Hifuhigh intensity focused ultrasound ruixi aesthetic. E16 february 2018 with 309 reads how we measure reads. Simultaneous treatment with marketleading devices harkermartinez, simon. By using the combination of high intensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions precisely. Though few regimens may offer a limited survival benefit, novel treatment strategies are urgently needed.
Highintensity focused ultrasound hifu is a promising noninvasive thermal ablation technique. When propagated into human tissue, the pressure waves are either reflected or absorbed. The technology can be used to treat a range of disorders and as of 2015 is at. Ultrasound beams are focused on fibroid, and accumulative energy of the beam at a focal point increases the temperature over 65c and destroys the outgrowth. Other ultrasound treatment methods include ultrasound assisted drug delivery. High intensity focused ultrasound hifu is a noninvasive therapeutic technique that uses nonionizing ultrasonic waves to heat tissue.